反应详情

α-Cyclopentyl-p-methoxyacetophenone (13.0 g, 0.06 mol) was added slowly in dry DME (DME=Dimethoxyethane) to the suspension of NaH (8 g, 55-60% dispersion, 0.018 mmol) in dry DME under N2 atmosphere at room temperature. The suspension was stirred over night. Ethyl iodide (27.7 g, 0.18 mmol) was added and stirring continued for another two hours. Ice water was added cautiously and the water layer extracted with toluene. The organic layer was washed with water, dried and evaporated to give 12.7 g (0.0052 mol, 86%) of the product.

1. stirringstirring
2. extractionthe water layer extracted with toluene
3. washThe organic layer was washed with water
4. customdried
5. customevaporated