Diisopropylethylamine → HCID 89720673, compound
Reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1([C:11]([NH:13][C@@H:14]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]3[C:26](=[O:35])[N:27]([CH3:34])[C:28](=[O:33])[N:29]([CH3:32])[C:30]=3[CH3:31])=[CH:21][CH:20]=2)[C:15]([OH:17])=[O:16])=[O:12])[CH2:10][CH2:9][CH2:8][CH2:7]1.O=C1CCC(=O)N1[O:43][C:44](=O)[CH2:45][CH2:46][O:47][CH2:48][CH2:49][O:50][CH2:51][CH2:52][O:53][CH2:54][CH2:55][O:56][CH2:57][CH2:58][NH:59][C:60](=[O:70])[CH2:61][CH2:62][N:63]1[C:67](=[O:68])[CH:66]=[CH:65][C:64]1=[O:69].CCN(C(C)C)C(C)C>>[O:69]=[C:64]1[CH:65]=[CH:66][C:67](=[O:68])[N:63]1[CH2:62][CH2:61][C:60]([NH:59][CH2:58][CH2:57][O:56][CH2:55][CH2:54][O:53][CH2:52][CH2:51][O:50][CH2:49][CH2:48][O:47][CH2:46][CH2:45][C:44]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1([C:11]([NH:13][C@@H:14]([CH2:18][C:19]2[CH:20]=[CH:21][C:22]([C:25]3[C:26](=[O:35])[N:27]([CH3:34])[C:28](=[O:33])[N:29]([CH3:32])[C:30]=3[CH3:31])=[CH:23][CH:24]=2)[C:15]([OH:17])=[O:16])=[O:12])[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:43])=[O:70]Participants
4
Procedure
The title compound was prepared using a similar procedure as described in Example 1, Step 11, starting from (S)-2-[[1-(4-aminobutyl)cyclopentanecarbonyl]amino]-3-[4-(1,3,6-trimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenyl]propionic acid (300 mg, 0.62 mmol), 3-[2-[2-[2-[[3-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-propionylamino]-ethoxy]ethoxy]ethoxy]ethoxy]propionic acid-2,5-dioxo-pyrrolidin-1-yl ester (318 mg, 0.62 mmol), and DIPEA (160 mg, 215 uL, 1.24 mmol), and after HPLC purification, resulted in a light yellow solid (274 mg, 50%). ES(+)-HRMS m/e calcd. for C44H62N6O13 (M+H)+ 883.4448, obsd. 883.4449.
Workup
- customafter HPLC purification
Sources & evidence
- ORD record
- ord-765e088887734132b1cd273d70542443
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09447035B2
Reaction notes
Loading…