Sodium hydride → HCID 13560306, compound

To a solution of o-mercaptobenzylalcohol (289 mg, 2.06 mmol) in dry dimethylformamide (3 mL) was added sodium hydride (60% dispersion in mineral oil, 83 mg, 2.07 mmol) portionwise and the mixture allowed to stir for 30 minutes. To the resulting solution was added dropwise a solution of 6-acetoxy-7-hydroxymethyl-3,4-dihydrobenzopyran acetate (543 mg, 2.06 mmol) in dry dimethylformamide and the mixture allowed to stir at room temperature under nitrogen for three hours, heated to 50° for 30 minutes, then allowed to cool and stir overnight. The reaction was quenched with 2.5N sodium hydroxide (2 mL) and after stirring for 30 minutes, the mixture was poured into water (75 mL). The aqueous mixture was neutralized with 2N hydrochloric acid (2.5 mL), extracted with ether (2×100 mL) and the ether extract washed with brine (3×100 mL), dried (Na2SO4) and concentrated. The crude product was purified by preparative HPLC (2:1 hexane/ethyl acetate as eluant) to afford 6-hydroxy-7-(2-hydroxymethylphenyl)thiomethyl-3,4-dihydrobenzopyran as a pale off-white solid, m.p. 140°-141° C.

1. stirringto stir at room temperature under nitrogen for three hours
2. temperatureheated to 50° for 30 minutes
3. temperatureto cool
4. stirringstir overnight
5. customThe reaction was quenched with 2.5N sodium hydroxide (2 mL)
6. stirringafter stirring for 30 minutes
7. additionthe mixture was poured into water (75 mL)
8. extractionextracted with ether (2×100 mL)
9. extractionthe ether extract
10. washwashed with brine (3×100 mL)
11. dry with materialdried (Na2SO4)
12. concentrationconcentrated
13. customThe crude product was purified by preparative HPLC (2:1 hexane/ethyl acetate as eluant)

ORD record

ord-f74597e5acf64cbba89caca33b82901b

Source dataset

uspto-grants-1985_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04558067