反应详情

A mixture containing 15.1 g of 5-acetyl-6-methyl-2(1H)-pyridinone, 200 ml of dimethylformamide and 15 ml of dimethylformamide dimethyl acetal was stirred at room temperature for 30 minutes, heated gently with stirring on a steam bath for 2 hours, then allowed to cool and stirred at room temperature overnight. The golden yellow needles that separated were collected, washed with methanol and dried in a vacuum oven at 80° C. to yield 10.7 g of 5-acetyl-6-(2-dimethylaminoethenyl)-2(1H)-pyridinone, m.p. 238°-240° C.

1. temperatureheated gently
2. stirringwith stirring on a steam bath for 2 hours
3. temperatureto cool
4. stirringstirred at room temperature overnight
5. customThe golden yellow needles that separated
6. customwere collected
7. washwashed with methanol
8. customdried in a vacuum oven at 80° C.