反应详情

A mixture containing 4.5 g of 5-methyl-1,6-naphthyridin-2(1H)-one, 15 ml of dimethylformamide and 4 ml of dimethylformamide dimethyl acetal was stirred at room temperature overnight, then heated on a steam bath for 7 hours and then evaporated to dryness on a rotary evaporator. The solid residue was recrystallized from isopropyl alcohol and dried at 90°-95° C. to yield 3.5 g of 1,5-dimethyl-1,6-naphthyridin-2(1H)-one, m.p. 203°-205° C.

1. temperatureheated on a steam bath for 7 hours
2. customevaporated to dryness on a rotary evaporator
3. customThe solid residue was recrystallized from isopropyl alcohol
4. customdried at 90°-95° C.