反应详情

温度

100 °C

A suspension (partial solution) of 25 g of dihydro-1H-pyrrolizine-3,5(2H,6H)-dione (III) in 150 ml of deionized water is treated with 0.1 ml of concentrated hydrochloric acid. The mixture is heated to reflux (100° C.) for 80 hours. Charcoal (0.5 g) is added and the mixture is filtered through filter aid. The solution is concentrated at reduced pressure, the 5-oxo-2-pyrrolidinepropanoic acid crystallizes and is isolated by filtration. After drying in vacuo the 5-oxo-2-pyrrolidinepropanoic acid has a melting point of 125°-127° C.

1. temperatureThe mixture is heated
2. filtrationthe mixture is filtered
3. filtrationthrough filter aid
4. concentrationThe solution is concentrated at reduced pressure
5. customthe 5-oxo-2-pyrrolidinepropanoic acid crystallizes
6. customis isolated by filtration
7. dry with materialAfter drying in vacuo the 5-oxo-2-pyrrolidinepropanoic acid