反应详情

A suspension of 10 g of 4-hydroxybiphenyl and 10 g of pulverised potassium carbonate in 75 ml of epichlorohydrin is stirred under reflux from 4 hours. The reaction mixture is concentrated by evaporation, water is added to the residue and the mixture is extracted with ethyl acetate. The organic phase is dried over sodium sulphate and concentrated by evaporation. The residue is recrystallised from isopropanol, yielding 4-(2,3-epoxypropoxy)-biphenyl having a melting point of 86°-88°.

1. temperatureunder reflux from 4 hours
2. concentrationThe reaction mixture is concentrated by evaporation, water
3. additionis added to the residue
4. extractionthe mixture is extracted with ethyl acetate
5. dry with materialThe organic phase is dried over sodium sulphate
6. concentrationconcentrated by evaporation
7. customThe residue is recrystallised from isopropanol