Propionyl chloride → HCID 13604086, compound

HRID 638141Notes

Reaction equation

HRID 638141 reaction equation
[Cl:1][C:2]1[C:10]2[O:9][CH:8]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH2:7][C:6]=2[CH:5]=[CH:4][C:3]=1[O:16]C.[C:18](Cl)(=[O:21])[CH2:19][CH3:20].[Cl-].[Al+3].[Cl-].[Cl-]>ClCCCl>[Cl:1][C:2]1[C:10]2[O:9][CH:8]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH2:7][C:6]=2[CH:5]=[C:4]([C:18](=[O:21])[CH2:19][CH3:20])[C:3]=1[OH:16]

Participants

5

Reactant 3

HCID 62324Propionyl chlorideHCID 6451240Aluminum(III) Chloride2×HCID 13343698HCID 13343698, compound

Product 1

HCID 13604086HCID 13604086, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

To 1,2-dichloroethane (50 ml) were added ethyl 7-chloro-2,3-dihydro-6-methoxybenzofuran-2-carboxylate (1b) (4.25 g, 0.01656 mol) and propionyl chloride (2.58 ml, 0.03311 mol). The solution was stirred on an ice bath and treated with anhydrous aluminum chloride (6.62 g, 0.04967 mol) at 0°-5° C. for 45 minutes. An additional portion of aluminum chloride (2.21 g, 0.01656 mol) was added and the mixture left to stir overnight.

Workup

  1. waitthe mixture left
  2. stirringto stir overnight

Sources & evidence

ORD record
ord-88da4d55e5e3420487d9219e58289097
Source dataset
uspto-grants-1985_12
Patent number
US04560558

Reaction notes

Loading…