Sodium Iodide → HCID 13450726, compound

HRID 638188Notes

Reaction equation

[C:1]([C:9]1[CH:26]=[CH:25][CH:24]=[CH:23][C:10]=1[NH:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:14][CH2:13]1)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:28][C:29](Cl)=[O:30].[I-].[Na+].C(=O)([O-])[O-].[NH4+:38].[NH4+]>>[CH2:21]([O:20][C:18]([N:15]1[CH2:16][CH2:17][CH:12]([N:11]2[C:10]3[CH:23]=[CH:24][CH:25]=[CH:26][C:9]=3[C:1]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[N:38][CH2:28][C:29]2=[O:30])[CH2:13][CH2:14]1)=[O:19])[CH3:22]

Participants

Reactant 4

HCID 5238Sodium Iodide

HCID 6577Chloroacetyl chloride

HCID 517111Ammonium Carbonate

HCID 13450696HCID 13450696, compound

Product 1

HCID 13450726HCID 13450726, compound

Procedure

The reactions are performed as in the method of Example 23 (d) and (e). Thus ethyl 4-(2-benzoylanilino)piperidine-1-carboxylate (2.56 g) is reacted successively with 2-chloro-acetyl chloride, sodium iodide and ammonium carbonate, whereby 1,3-dihydro-1-(1-ethoxycarbonyl-4-piperidinyl)-5-phenyl-2H-1,4-benzodiazepin-2-one (2.27 g) is obtained as a powder.

Sources & evidence

ORD record: ord-380c7b50a20c445c8e04908eaed0530d
Source dataset: uspto-grants-1985_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04560684

Reaction notes

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