Trifluoroacetic acid → HCID 66744955, compound

HRID 63826Notes

Reaction equation

HRID 63826 reaction equation
[Cl:1][C:2]1[C:3]([F:14])=[C:4]([C:7]([C:10]([F:13])([F:12])[F:11])=[CH:8][CH:9]=1)[CH:5]=O.ClC1C=CC(OC(F)F)=C(C=1)C=O.[C:28]([OH:34])([C:30](F)(F)F)=[O:29]>>[Cl:1][C:2]1[C:3]([F:14])=[C:4](/[CH:5]=[CH:30]/[C:28]([OH:34])=[O:29])[C:7]([C:10]([F:13])([F:12])[F:11])=[CH:8][CH:9]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7363373-Chloro-2-fluoro-6-(trifluoromethyl)benzaldehydeHCID 47709495-Chloro-2-(difluoromethoxy)benzaldehyd

Product 1

HCID 66744955HCID 66744955, compound

Procedure

Intermediate 16 was made in a similar manner as Intermediate 15 substituting 3-chloro-2-fluoro-6-(trifluoromethyl)benzaldehyde for 5-chloro-2-(difluoromethoxy) benzaldehyde followed by TFA deprotection. MS (ESI) m/z: 292 (M+Na)+. 1H NMR (400 MHz, CDCl3) δ 7.87 (1H, dd, J=16.17, 2.02 Hz), 7.49-7.62 (2H, m), 6.67 (1H, dd, J=16.30, 1.39 Hz) ppm.

Sources & evidence

ORD record
ord-748906ec93a946de997697d1b42a06f3
Source dataset
uspto-grants-2016_09
Patent number
US09447110B2

Reaction notes

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