Ethanol → HCID 13603935, compound

HRID 638274Notes

Reaction equation

HRID 638274 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([F:12])[CH:10]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:3]=1.[NH:19]1[CH2:29][CH2:28][CH:22]([C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH2:21][CH2:20]1.C(O)C>O>[CH2:26]([O:25][C:23]([CH:22]1[CH2:28][CH2:29][N:19]([C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([F:12])[CH:10]=3)[N:5]=[C:4]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH:3]=2)[CH2:20][CH2:21]1)=[O:24])[CH3:27]

Participants

5

Reactant 3

HCID 702EthanolHCID 70770Ethyl 4-piperidinecarboxylateHCID 136038964-Chloro-6-fluoro-2-phenylquinoline

Product 1

HCID 13603935HCID 13603935, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 9.0 g of 4-chloro-6-fluoro-2-phenylquinoline prepared according to the procedure described in example 9(b) and 18 ml of ethyl isonipecotate was stirred and heated in an oil bath at 160°-165° for 2 hr. It was then cooled and diluted with water. Addition of ethanol caused a solid to form which was collected to give 7.2 g of product as white prisms, mp 120°-124°.

Workup

  1. customprepared
  2. temperatureheated in an oil bath at 160°-165° for 2 hr
  3. temperatureIt was then cooled
  4. customto form which
  5. customwas collected

Sources & evidence

ORD record
ord-0349178e721048998d54e8bf1c3c74e6
Source dataset
uspto-grants-1985_12
Patent number
US04560692

Reaction notes

Loading…