Phosphorus oxychloride → 4,6-Dichloroquinoline

HRID 638290Notes

Reaction equation

HRID 638290 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2O.P(Cl)(Cl)([Cl:15])=O>>[Cl:15][C:5]1[C:4]2[C:9](=[CH:10][CH:11]=[C:2]([Cl:1])[CH:3]=2)[N:8]=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178516411HCID 178516411, compound

Product 1

HCID 9360754,6-Dichloroquinoline

Procedure

From 93.6 g of 6-chloro-4-hydoxyquinoline and 200 ml of phosphorus oxychloride reacted in a manner similar to that described in Example 2(b) there was obtained 63.6 g of the above named compound as white needles, mp 101°-104°.

Workup

  1. customwas obtained 63.6 g of the

Sources & evidence

ORD record
ord-b90b6f26cb704649b24b81b4c3efc9cf
Source dataset
uspto-grants-1985_12
Patent number
US04560692

Reaction notes

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