Phosphorus oxychloride → 4,6-Dichloro-2-phenylquinoline

HRID 638296Notes

Reaction equation

HRID 638296 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:6]=[C:5]2O.P(Cl)(Cl)([Cl:21])=O>>[Cl:21][C:5]1[C:4]2[C:9](=[CH:10][CH:11]=[C:2]([Cl:1])[CH:3]=2)[N:8]=[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178515553HCID 178515553, compound

Product 1

HCID 136039384,6-Dichloro-2-phenylquinoline

Procedure

From 25.5 g of 6-chloro-2-phenyl-4-quinolinol and 50 ml of phosphorus oxychloride treated according to the procedure of Example 4(b) there was obtained 24.86 g of 4,6-dichloro-2-phenylquinoline, mp 114°-116°.

Sources & evidence

ORD record
ord-d8bf31bbd7074920a2317e38d911e4b1
Source dataset
uspto-grants-1985_12
Patent number
US04560692

Reaction notes

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