Anisole → HCID 178506579, compound

HRID 638325Notes

Reaction equation

HRID 638325 reaction equation
C(OC([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][CH2:15][I:16])[N:10]=[CH:9]1)=O)(C)(C)C.C1(OC)C=CC=CC=1>FC(F)(F)C(O)=O>[NH:8]1[CH:12]=[C:11]([CH2:13][CH2:14][CH2:15][I:16])[N:10]=[CH:9]1

Participants

4

Reactant 2

HCID 7519AnisoleHCID 20253489HCID 20253489, compound

Product 1

HCID 178506579HCID 178506579, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 5 g (14.2 mmol) of 3-(1-t-butyloxycarbonylimidazol-4-yl)-1-iodopropane (prepared as described in Example 6, part C) is stirred in a mixture of 5 ml of trifluoroacetic acid, 5 ml of CH2CH2 and 1 ml of anisole at 0° C. under nitrogen for 6 hours, then concentrated in vacuo and partitioned between CHCl3 and 15% aq Na2CO3. Evaporation of the organic extracts affords the title A compound.

Workup

  1. concentrationconcentrated in vacuo
  2. custompartitioned between CHCl3 and 15% aq Na2CO3
  3. customEvaporation of the organic extracts
  4. customaffords the title A compound

Sources & evidence

ORD record
ord-e8f67b447f514bd3bffe958723ab1c8b
Source dataset
uspto-grants-1985_12
Patent number
US04560680

Reaction notes

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