Methanol → HCID 70450173, compound

HRID 638545Notes

Reaction equation

HRID 638545 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([OH:18])([C:14]([O:16]C)=[O:15])[C:10](OC)=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8].[CH3:19][NH2:20].[CH3:21]O>>[CH3:19][N:20]([CH3:21])[C:10](=[O:11])[C:9]([C:4]1[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=1)([OH:18])[C:14]([OH:16])=[O:15]

Participants

4

Reactant 3

HCID 887MethanolHCID 6329MethylamineHCID 13361971HCID 13361971, compound

Product 1

HCID 70450173HCID 70450173, compound

Procedure

14.7 g of dimethyl 3,4-dichlorophenylhydroxymalonate were dissolved in 100 ml of methanol, and methylamine was passed in for 1 hour at 60° C. The mixture was evaporated down completely and the crystalline residue was recrystallized from 100 ml of ethanol. 12 g of 3,4-dichlorophenylhydroxymalonic acid dimethylamide (m.p.=158°-60° C.) were obtained.

Workup

  1. customwas passed in for 1 hour at 60° C
  2. customThe mixture was evaporated down completely
  3. customthe crystalline residue was recrystallized from 100 ml of ethanol

Sources & evidence

ORD record
ord-86973c67b65a4d65983373be643beb63
Source dataset
uspto-grants-1985_12
Patent number
US04562185

Reaction notes

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