反应详情

13.4 g of 2-(1,2-dichlorovinyloxy)phenylsulfonamide and 3.65 g of methyl isothiocyanate are dissolved in 50 ml of acetonitrile, and 7.8 g of 1,8-diazabicyclo[5.4.0]undec-7-ene are added with cooling (0° to 5° C.) and stirring. The resulting red reaction solution is left to stand for 24 hours, 4.8 g of methanesulfonic acid are then added and the mixture is diluted with water to a volume of 1 liter. The crystals which separate out are filtered off, washed with methanol and dried. Yield: 15 g. Melting point: 185°-187° (decomposition).

1. temperaturewith cooling (0° to 5° C.)
2. waitThe resulting red reaction solution is left
3. customThe crystals which separate out
4. filtrationare filtered off
5. washwashed with methanol
6. customdried