反应详情

To a mixture of Capsaicin (2 g, 6.56 mmol), anhydrous K2CO3 (3 g, 22 mmol), and sodium iodide (2 g, 14.2 mmol) in anhydrous acetone (50 ml) was added methyl 2-chloropropionate (1.2 g, 10 mmol) and refluxed for 16 hours. Acetone was distilled off and water (15 ml) was added. Crude 11 was filtered, dried and recrystallised from a mixture of chloroform:hexane (1:5) to give pure 11 (0.8 g, 31.2%) as a white powder. The melting point was found to be 62.3-64° C.

1. temperaturerefluxed for 16 hours
2. distillationAcetone was distilled off
3. additionwater (15 ml) was added
4. filtrationCrude 11 was filtered
5. customdried
6. customrecrystallised from a mixture of chloroform:hexane (1:5)