Aluminium lithium hydride → HCID 68712490, compound

HRID 638805Notes

Reaction equation

HRID 638805 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]=1[Cl:15])[CH2:5][N:6]1[CH2:9][CH:8]([C:10]#[N:11])[CH2:7]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]=1[Cl:15])[CH2:5][N:6]1[CH2:9][CH:8]([CH2:10][NH2:11])[CH2:7]1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 687084431-(3,4-Dichloro-benzyl)-azetidine-3-carbonitrile

Product 1

HCID 68712490HCID 68712490, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of 1-(3,4-Dichloro-benzyl)-azetidine-3-carbonitrile (0.083 g, 0.347 mmol) in dry THF (2 ml) cooled to 0° C. is treated with a 1.0 M solution of lithium aluminium hydride in THF (0.347 ml). The reaction mixture is allowed to warm to ambient temperature and stirred for a one hour. The reaction mixture is quenched with saturated sodium sulphate solution and filtered. The filtrate is evaporated to afford the title compound. [MH] 244.97.

Workup

  1. customThe reaction mixture is quenched with saturated sodium sulphate solution
  2. filtrationfiltered
  3. customThe filtrate is evaporated

Sources & evidence

ORD record
ord-c8f863142151472fb2475069e962fa41
Source dataset
uspto-grants-2010_04
Patent number
US07691841B2

Reaction notes

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