反应详情

温度

0 °C

To a suspension of dried 4-bromo-6-(methyloxy)-3-quinolinecarboxylic acid (1.4 g, 5 mmol) in CH2Cl2 (20 mL) at 0° C. was added oxalyl chloride (2M in CH2Cl2, 5.0 mL, 10 mmol). After 1 h, an aliquot was quenched with NH4OH and LCMS indicated desired product was formed. Excess NH4OH (2 mL) was slowly added to the reaction solution, maintained at 0° C. (very exothermic), and the reaction was stirred an additional 2 h. The product was isolated via filtration to give 1.0 g (83%).

1. customan aliquot was quenched with NH4OH and LCMS
2. customwas formed
3. customThe product was isolated via filtration
4. customto give 1.0 g (83%)