HRID638973

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6871

Diethyl ethoxymethylenemalonate

C10H16O5

HCID81121

Pyridine, 5-amino-2-methoxy-

C6H8N2O

PRODUCTS

生成物

HCID619151

Diethyl {[(6-methoxypyridin-3-yl)amino]methylidene}propanedioate

C14H18N2O5

收率 100.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A solution of 5-amino-2-methoxypyridine (Aldrich, 100 g, 0.806 mole) and diethyl ethoxymethylenemalonate (Aldrich, 163 mL, 0.806 mole) in EtOH (1 L) was heated at reflux for 4 hours, then was cooled to RT. Concentration to dryness gave the title compound (238 g, quantitative).

WORKUP

后处理

temperatureat reflux for 4 hours
concentrationConcentration to dryness