反应详情

To a solution of (S)-3-(aminomethyl)-1-N-Boc-pyrrolidine (3.0 g, 14.98 mmole) in DMF (40 mL) was added triethylamine (2.5 mL, 17.94 mmole) and N-(benzyloxycarbonyloxy)succinimide (4.46 g, 17.90 mmole). After 18 hours, the reaction solution was concentrated under vacuum and redissolved in diethyl ether (250 mL). The organic solution was washed with H2O (2×150 mL), brine (100 mL) and dried over Na2SO4 and concentrated. The remaining residue was purified on silica (CHCl3/MeOH, 9:1 containing 5% NH4OH) to give the title compound (4.46 g, 91%) as a light yellow oil: LC-MS (ES) m/e 335 (M+H)+.

1. concentrationthe reaction solution was concentrated under vacuum
2. dissolutionredissolved in diethyl ether (250 mL)
3. washThe organic solution was washed with H2O (2×150 mL), brine (100 mL)
4. dry with materialdried over Na2SO4
5. concentrationconcentrated
6. customThe remaining residue was purified on silica (CHCl3/MeOH, 9:1 containing 5% NH4OH)