Potassium Carbonate → HCID 59026168, compound

HRID 639067Notes

Reaction equation

HRID 639067 reaction equation
C(OC(=O)[NH:5][CH2:6][C@@H:7]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[C:21]([O:24][CH3:25])[N:22]=3)[N:17]=[CH:16][CH:15]=2)[CH2:8]1)C.C(=O)([O-])[O-].[K+].[K+]>CO.O>[CH3:25][O:24][C:21]1[N:22]=[C:23]2[C:18](=[CH:19][CH:20]=1)[N:17]=[CH:16][CH:15]=[C:14]2[CH2:13][CH2:12][N:9]1[CH2:10][CH2:11][C@@H:7]([CH2:6][NH2:5])[CH2:8]1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 90845533HCID 90845533, compound

Product 1

HCID 59026168HCID 59026168, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a stirred solution of ethyl[((3S)-1-{2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]carbamate (0.80 g, 2.09 mmole) in MeOH (30 mL) and H2O (15 mL) at RT was added potassium carbonate (1.44 g, 10.5 mmole). After 18 h, the reaction contents were concentrated under reduced pressure and filtered through celite (EtOH) to give the title compound (0.59 g, 99%) as a light brown oil: LC-MS (ES) m/e 289 (M+H)+.

Workup

  1. customthe reaction contents
  2. concentrationwere concentrated under reduced pressure
  3. filtrationfiltered through celite (EtOH)

Sources & evidence

ORD record
ord-d0ecaca072a64978b7bc1d46c77d1452
Source dataset
uspto-grants-2010_04
Patent number
US07691850B2

Reaction notes

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