Piperidine → HCID 17365703, compound

HRID 639145Notes

Reaction equation

HRID 639145 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH2:10][C:11]#[N:12].[C:13]([C:15]1[CH:22]=[CH:21][C:18]([CH:19]=O)=[CH:17][CH:16]=1)#[N:14].N1CCCCC1>C(O)C>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1/[C:10](/[C:11]#[N:12])=[CH:19]\[C:18]1[CH:21]=[CH:22][C:15]([C:13]#[N:14])=[CH:16][CH:17]=1

Participants

5

Reactant 3

HCID 8082PiperidineHCID 660424-CyanobenzaldehydeHCID 3424652-(1,3-Benzothiazol-2-yl)acetonitrile

Product 1

HCID 17365703HCID 17365703, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Benzothiazole-2-acetonitrile (750 mg, 4.3 mmol) and 4-cyanobenzaldehyde (564 mg, 4.3 mmol) are dissolved in ethanol (20 ml). Piperidine (11 mg, 0.13 mmol) is added, and the reaction is stirred at room temperature for 2 hours. A precipitate is formed, which is filtered and washed with additional ethanol (5 ml). The solid is dried in a vacuum desiccator overnight and used without further purification.

Workup

  1. customA precipitate is formed
  2. filtrationwhich is filtered
  3. washwashed with additional ethanol (5 ml)
  4. customThe solid is dried in a vacuum desiccator overnight
  5. customused without further purification

Sources & evidence

ORD record
ord-0fa658fb2c884e38ad26b0dc6d55e4ee
Source dataset
uspto-grants-2010_04
Patent number
US07691854B2

Reaction notes

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