反应详情

6-Methylnicotinonitrile (3.68 g, 31.15 mmol) is dissolved in chloroform (60 ml). 3-Chloroperoxybenzoic acid (7.53 g, 32.71 mmol) is added dropwise as a solution in chloroform (60 ml), and the solution is stirred at room temperature overnight. Sodium sulphite (2.92 g, 23.17 mmol) is added, and the resulting mixture is stirred for one hour. The reaction is quenched with saturated sodium bicarbonate solution, and the product is extracted with chloroform (500 ml). The organic phase is washed with brine, dried over magnesium sulphate monohydrate, filtered and concentrated in vacuo. The residue is used without further purification.

1. stirringthe resulting mixture is stirred for one hour
2. customThe reaction is quenched with saturated sodium bicarbonate solution
3. extractionthe product is extracted with chloroform (500 ml)
4. washThe organic phase is washed with brine
5. dry with materialdried over magnesium sulphate monohydrate
6. filtrationfiltered
7. concentrationconcentrated in vacuo
8. customThe residue is used without further purification