Hydrazine hydrate (1:1) → HCID 178503423, compound

HRID 639389Notes

Reaction equation

HRID 639389 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=O)[CH2:10][C:11]1[CH:16]=[CH:15][N:14]=[C:13]([S:17][CH3:18])[N:12]=1.COC(OC)[N:23]([CH3:25])C.O.[NH2:29]N>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:10]([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([S:17][CH3:18])[N:12]=2)=[CH:25][NH:23][N:29]=1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 78373Dimethylformamide dimethyl acetalHCID 586416531-(2,4-Dichlorophenyl)-2-[2-(methylsulfanyl)pyrimidin-4-yl]ethan-1-one

Product 1

HCID 178503423HCID 178503423, compound

Procedure

The title compound is prepared from 1-(2,4-dichloro-phenyl)-2-(2-methylsulfanyl-pyrimidin-4-yl)-ethanone as described in Example 1, Step 1.3, using N,N-dimethylformamid-dimethylacetal and hydrazine monohydrate. Title compound: m.p.: 218-219° C.; single peak at 6.07 min (System 1).

Sources & evidence

ORD record
ord-a661290bfe2d44598899e9f0af0aff52
Source dataset
uspto-grants-2010_04
Patent number
US07691855B2

Reaction notes

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