Triethylamine → HCID 11384330, compound

HRID 639439Notes

Reaction equation

HRID 639439 reaction equation
[CH3:1][CH:2]([S:4](Cl)(=[O:6])=[O:5])[CH3:3].C(N(CC)CC)C.Cl.[C@@H:16]12[CH2:23][NH:22][CH2:21][C@@H:20]1[CH2:19][N:18]([C:24]1[NH:25][C:26]3[CH:32]=[C:31]([C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=4)[CH:30]=[CH:29][C:27]=3[N:28]=1)[CH2:17]2>C1COCC1>[CH:2]([S:4]([N:22]1[CH2:21][C@@H:20]2[C@@H:16]([CH2:17][N:18]([C:24]3[NH:25][C:26]4[CH:32]=[C:31]([C:33]5[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=5)[CH:30]=[CH:29][C:27]=4[N:28]=3)[CH2:19]2)[CH2:23]1)(=[O:6])=[O:5])([CH3:3])[CH3:1]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 824082-Propanesulfonyl chlorideHCID 68428151HCID 68428151, compound

Product 1

HCID 11384330HCID 11384330, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-Propanesulfonyl chloride and triethylamine were added to the THF suspension (5 mL) containing 2-(cis-3,7-diazabicyclo[3.3.0]oct-3-yl)-5-phenylbenzimidazole hydrochloride (26 mg) at room temperature, followed by stirring for 15 min. The reaction mixture was concentrated under reduced pressure, and the residue was separated and purified on a collective thin-layer chromatograph (chloroform:methanol=10:1) to give the title compound (12 mg).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was separated
  3. custompurified on a collective thin-layer chromatograph (chloroform:methanol=10:1)

Sources & evidence

ORD record
ord-db1d14dd82a84bc5a514154cb8b89126
Source dataset
uspto-grants-2010_04
Patent number
US07691860B2

Reaction notes

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