反应详情

To a stirred solution of 3-hydroxymorphinan (5 mg, 0.015 mmol) and triethylamine (13 μL, 0.091 mmol) in dry dichloromethane (0.3 mL) was added benzyl chloroformate (5.2 μL, 0.036 mmol) at 0° C. The reaction mixture was stirred for 2 h at room temperature. After starting material disappeared on TLC, solvent was removed and column chromatography gave 6.3 mg (80%) of title compound: 1H NMR (300 MHz, CDCl3) δ7.3˜7.6 (10H, m); 7.0 (2H, m); 6.9 (1H, m); 5.3 (2H, s); 5.1 (2H, s); 4.3 (1H, dd); 3.9 (1H, m); 3.1 (1H, m); 2.7 (2H, d); 2.3 (1H, m); 1.0˜1.8 (10H, m).

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