Thiazole → (2-Amino-3-nitro-6-thiazol-2-yl-pyridin-4-yl)-(6-methyl-pyridin-3-ylmethyl)-carbamic acid ethyl ester

HRID 639656Notes

Reaction equation

HRID 639656 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[CH2:6]([O:8][C:9](=[O:30])[N:10]([C:19]1[CH:24]=[C:23](Br)[N:22]=[C:21]([NH2:26])[C:20]=1[N+:27]([O-:29])=[O:28])[CH2:11][C:12]1[CH:13]=[N:14][C:15]([CH3:18])=[CH:16][CH:17]=1)[CH3:7]>>[CH2:6]([O:8][C:9](=[O:30])[N:10]([C:19]1[CH:24]=[C:23]([C:2]2[S:1][CH:5]=[CH:4][N:3]=2)[N:22]=[C:21]([NH2:26])[C:20]=1[N+:27]([O-:29])=[O:28])[CH2:11][C:12]1[CH:13]=[N:14][C:15]([CH3:18])=[CH:16][CH:17]=1)[CH3:7]

Participants

3

Reactant 2

HCID 9256ThiazoleHCID 86614483(2-Amino-6-bromo-3-nitro-pyridin-4-yl)-(6-methyl-pyridin-3-ylmethyl)-carbamic acid ethyl ester

Product 1

HCID 67457212(2-Amino-3-nitro-6-thiazol-2-yl-pyridin-4-yl)-(6-methyl-pyridin-3-ylmethyl)-carbamic acid ethyl ester

Procedure

The title compound was prepared following the example in preparation 70, using thiazole (42 mg) and (2-amino-6-bromo-3-nitro-pyridin-4-yl)-(6-methyl-pyridin-3-ylmethyl)-carbamic acid ethyl ester (100 mg), giving the product (79 mg) as a yellow gum.

Workup

  1. customin preparation 70

Sources & evidence

ORD record
ord-5c5b989f325a4d1eac8e83d3c6a0cca7
Source dataset
uspto-grants-2010_04
Patent number
US07691877B2

Reaction notes

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