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HRID639707

反应详情

EQUATION

反应方程式

HRID 639707 的结构方程式

REACTANTS

反应物

4
结构：ClCCl
HCID6344

Dichloromethane

CH2Cl2

结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：C=C[B-](F)(F)F.[K+]
HCID23679353

Potassium ethenyl(trifluoro)borate(1-)

C2H3BF3K

结构：CCOC(=O)N(Cc1ccc(C)nc1)c1cc(Cl)nc(N)c1[N+](=O)[O-]
HCID57856581

未命名化合物

PRODUCTS

生成物

1
结构：C=Cc1cc(N(Cc2ccc(C)nc2)C(=O)OCC)c([N+](=O)[O-])c(N)n1
HCID67457433

未命名化合物

收率 38.6%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：Cl[Pd]Cl.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1
催化剂HCID178418228

未命名化合物

结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

CONDITIONS

反应条件

温度
50 °C

PROCEDURE

实验过程

(2-Amino-6-chloro-3-nitro-pyridin-4-yl)-(6-methyl-pyridin-3-ylmethyl)-carbamic acid ethyl ester (715 mgs/1.955 mmols), potassium vinyltrifluoroborate (415 mgs/3.098 mmols), [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium(II).CH2Cl2 (90 mgs/0.11 mmols) and triethylamine (0.28 mls/2.0 mmols) were combined in iPrOH (8.0 mls) and heated at 50° C. under N2 for 24 hrs. Preadsorbed directly onto silica and purified by column chromatography to give title compound (270 mgs) as a purple resin

WORKUP

后处理

  1. customPreadsorbed directly onto silica and purified by column chromatography