Dimethylformamide → HCID 68431672, compound

HRID 639815Notes

Reaction equation

HRID 639815 reaction equation
I[C:2]1[CH:3]=[C:4]([N:8]2[N:12]=[N:11][C:10]([CH:13]([O:15][C:16]3[N:17]([CH3:27])[C:18]([C:21]4[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=4)=[N:19][N:20]=3)[CH3:14])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[CH3:28][N:29](C=O)C>[C-]#N.[Zn+2].[C-]#N>[CH3:27][N:17]1[C:18]([C:21]2[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=2)=[N:19][N:20]=[C:16]1[O:15][CH:13]([C:10]1[N:11]=[N:12][N:8]([C:4]2[CH:3]=[C:2]([CH:7]=[CH:6][CH:5]=2)[C:28]#[N:29])[N:9]=1)[CH3:14]

Participants

4

Reactant 2

HCID 6228DimethylformamideHCID 68431713HCID 68431713, compound

Product 1

HCID 68431672HCID 68431672, compound

Reagents, catalysts & solvents 1

HCID 11186Zinc cyanide (Zn(CN)2)Catalyst

Procedure

The title compound is prepared from 4-(5-{1-[2-(3-iodo-phenyl)-2H-tetrazol-5-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine (1 mmol), zinc cyanide (1.1 mmol), palladium (0) tetrakis-triphenylphosphine (0.05 mmol) in DMF (5 mL) at 80° C. overnight.

Sources & evidence

ORD record
ord-89eeac7fd9a444c4ae4947231dbd6dcd
Source dataset
uspto-grants-2010_04
Patent number
US07691892B2

Reaction notes

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