Dimethylformamide → HCID 68431898, compound

HRID 639816Notes

Reaction equation

HRID 639816 reaction equation
[CH:1]1([N:4]2[C:8]([O:9][CH2:10][C:11]3[N:12]=[N:13][N:14]([C:16]4[CH:21]=[CH:20][CH:19]=[C:18](I)[CH:17]=4)[N:15]=3)=[N:7][N:6]=[C:5]2[C:23]2[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=2)[CH2:3][CH2:2]1.[CH3:29][N:30](C=O)C>[C-]#N.[Zn+2].[C-]#N>[CH:1]1([N:4]2[C:5]([C:23]3[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=3)=[N:6][N:7]=[C:8]2[O:9][CH2:10][C:11]2[N:12]=[N:13][N:14]([C:16]3[CH:17]=[C:18]([CH:19]=[CH:20][CH:21]=3)[C:29]#[N:30])[N:15]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 6228DimethylformamideHCID 68431011HCID 68431011, compound

Product 1

HCID 68431898HCID 68431898, compound

Reagents, catalysts & solvents 1

HCID 11186Zinc cyanide (Zn(CN)2)Catalyst

Procedure

The title compound is prepared from 4-{4-cyclopropyl-5-[2-(3-iodo-phenyl)-2H-tetrazol-5-ylmethoxy]-4H-[1,2,4]triazol-3-yl}-pyridine (1 mmol), zinc cyanide (1.1 mmol), palladium (0) tetrakis-triphenylphosphine (0.05 mmol) in DMF (5 mL) at 80° C. overnight.

Sources & evidence

ORD record
ord-f8a66941e79a4e8fb75379359d2fbdb7
Source dataset
uspto-grants-2010_04
Patent number
US07691892B2

Reaction notes

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