Dimethylformamide → HCID 68431042, compound

HRID 639817Notes

Reaction equation

HRID 639817 reaction equation
[CH:1]1([N:4]2[C:8]([O:9][CH:10]([C:12]3[N:13]=[N:14][N:15]([C:17]4[CH:22]=[CH:21][CH:20]=[C:19](I)[CH:18]=4)[N:16]=3)[CH3:11])=[N:7][N:6]=[C:5]2[C:24]2[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=2)[CH2:3][CH2:2]1.[CH3:30][N:31](C=O)C>[C-]#N.[Zn+2].[C-]#N>[CH:1]1([N:4]2[C:5]([C:24]3[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=3)=[N:6][N:7]=[C:8]2[O:9][CH:10]([C:12]2[N:13]=[N:14][N:15]([C:17]3[CH:18]=[C:19]([CH:20]=[CH:21][CH:22]=3)[C:30]#[N:31])[N:16]=2)[CH3:11])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 6228DimethylformamideHCID 68431012HCID 68431012, compound

Product 1

HCID 68431042HCID 68431042, compound

Reagents, catalysts & solvents 1

HCID 11186Zinc cyanide (Zn(CN)2)Catalyst

Procedure

The title compound is prepared from 4-(4-cyclopropyl-5-{1-[2-(3-iodo-phenyl)-2H-tetrazol-5-yl]-ethoxy}-4H-[1,2,4]triazol-3-yl)-pyridine (1 mmol), zinc cyanide (1.1 mmol), palladium (0) tetrakis-triphenylphosphine (0.05 mmol) in DMF (5 mL) at 80° C. overnight.

Sources & evidence

ORD record
ord-89ade5c3915b44c0a65c2f31a04a95e6
Source dataset
uspto-grants-2010_04
Patent number
US07691892B2

Reaction notes

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