Dimethylformamide → HCID 11675373, compound

HRID 639820Notes

Reaction equation

HRID 639820 reaction equation
I[C:2]1[CH:3]=[C:4]([N:8]2[N:12]=[N:11][C:10]([CH2:13][N:14]3[CH2:19][CH2:18][CH2:17][N:16]4[C:20]([C:23]5[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=5)=[N:21][N:22]=[C:15]34)=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[CH3:29][N:30](C=O)C>[C-]#N.[Zn+2].[C-]#N>[N:26]1[CH:27]=[CH:28][C:23]([C:20]2[N:16]3[CH2:17][CH2:18][CH2:19][N:14]([CH2:13][C:10]4[N:11]=[N:12][N:8]([C:4]5[CH:3]=[C:2]([CH:7]=[CH:6][CH:5]=5)[C:29]#[N:30])[N:9]=4)[C:15]3=[N:22][N:21]=2)=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 6228DimethylformamideHCID 11518698HCID 11518698, compound

Product 1

HCID 11675373HCID 11675373, compound

Reagents, catalysts & solvents 1

HCID 11186Zinc cyanide (Zn(CN)2)Catalyst

Procedure

The title compound is prepared from 8-[2-(3-iodo-phenyl)-2H-tetrazol-5-ylmethyl]-3-pyridin-4-yl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine (1 mmol), zinc cyanide (1.1 mmol), palladium (0) tetrakis-triphenylphosphine (0.05 mmol) in DMF (5 mL) at 80° C. overnight.

Sources & evidence

ORD record
ord-aad6a842a04d4aa08058750eaafb8542
Source dataset
uspto-grants-2010_04
Patent number
US07691892B2

Reaction notes

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