Dimethylformamide → HCID 11696953, compound

HRID 639821Notes

Reaction equation

HRID 639821 reaction equation
I[C:2]1[CH:3]=[C:4]([N:8]2[N:12]=[N:11][C:10]([CH:13]([N:15]3[CH2:20][CH2:19][CH2:18][N:17]4[C:21]([C:24]5[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=5)=[N:22][N:23]=[C:16]34)[CH3:14])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[CH3:30][N:31](C=O)C>[C-]#N.[Zn+2].[C-]#N>[N:27]1[CH:26]=[CH:25][C:24]([C:21]2[N:17]3[CH2:18][CH2:19][CH2:20][N:15]([CH:13]([C:10]4[N:11]=[N:12][N:8]([C:4]5[CH:3]=[C:2]([CH:7]=[CH:6][CH:5]=5)[C:30]#[N:31])[N:9]=4)[CH3:14])[C:16]3=[N:23][N:22]=2)=[CH:29][CH:28]=1

Participants

4

Reactant 2

HCID 6228DimethylformamideHCID 11598513HCID 11598513, compound

Product 1

HCID 11696953HCID 11696953, compound

Reagents, catalysts & solvents 1

HCID 11186Zinc cyanide (Zn(CN)2)Catalyst

Procedure

The title compound is prepared from 8-{1-[2-(3-iodo-phenyl)-2H-tetrazol-5-yl]-ethyl}-3-pyridin-4-yl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine (1 mmol), zinc cyanide (1.1 mmol), palladium (0) tetrakis-triphenylphosphine (0.05 mmol) in DMF (5 mL) at 80° C. overnight.

Sources & evidence

ORD record
ord-c407d07fc55e43a5a0111461472ecdac
Source dataset
uspto-grants-2010_04
Patent number
US07691892B2

Reaction notes

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