Dimethylformamide → HCID 11531686, compound

HRID 639823Notes

Reaction equation

HRID 639823 reaction equation
I[C:2]1[CH:3]=[C:4]([N:8]2[N:12]=[N:11][C:10]([CH:13]([N:15]3[C:24]4[N:20]([C:21]([C:25]5[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=5)=[N:22][N:23]=4)[CH2:19][CH2:18][CH2:17][CH2:16]3)[CH3:14])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[CH3:31][N:32](C=O)C>[C-]#N.[Zn+2].[C-]#N>[N:28]1[CH:29]=[CH:30][C:25]([C:21]2[N:20]3[C:24]([N:15]([CH:13]([C:10]4[N:11]=[N:12][N:8]([C:4]5[CH:3]=[C:2]([CH:7]=[CH:6][CH:5]=5)[C:31]#[N:32])[N:9]=4)[CH3:14])[CH2:16][CH2:17][CH2:18][CH2:19]3)=[N:23][N:22]=2)=[CH:26][CH:27]=1

Participants

4

Reactant 2

HCID 6228DimethylformamideHCID 11642034HCID 11642034, compound

Product 1

HCID 11531686HCID 11531686, compound

Reagents, catalysts & solvents 1

HCID 11186Zinc cyanide (Zn(CN)2)Catalyst

Procedure

The title compound is prepared from 8-{1-[2-(3-iodo-phenyl)-2H-tetrazol-5-yl]-ethyl}-3-pyridin-4-yl-5,6,7,8-tetrahydro-4H-1,2,3a,8-tetraaza-azulene (1 mmol), zinc cyanide (1.1 mmol), palladium (0) tetrakis-triphenylphosphine (0.05 mmol) in DMF (5 mL) at 80° C. overnight.

Sources & evidence

ORD record
ord-23ab0694a7fe43b69c18e9206f1c4540
Source dataset
uspto-grants-2010_04
Patent number
US07691892B2

Reaction notes

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