Hydrochloric Acid → HCID 68547925, compound

HRID 639859Notes

Reaction equation

HRID 639859 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@:9]23[CH2:15][C@@:14]2([CH2:16][O:17][CH3:18])[CH2:13][N:12]([CH3:19])[CH2:11][CH2:10]3)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl>C(OCC)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C@:9]23[CH2:15][C@@:14]2([CH2:16][O:17][CH3:18])[CH2:13][N:12]([CH3:19])[CH2:11][CH2:10]3)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 24802847HCID 24802847, compound

Product 1

HCID 68547925HCID 68547925, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

(1S,6R)-6-(3,4-dichlorophenyl)-3-methyl-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane (E12, 16 mg) was treated with hydrochloric acid 1.0M in diethyl ether (0.064 mL). 0.5 mL of diethyl ether were added and a colourless solid formed. Organic phase was removed after decantation of the solid. Colourless solid obtained as a 5:1 mixture of isomers due protonation on the nitrogen atom (16 mg).

Workup

  1. customa colourless solid formed
  2. customOrganic phase was removed after decantation of the solid
  3. customColourless solid obtained as a 5:1 mixture of isomers due protonation on the nitrogen atom (16 mg)

Sources & evidence

ORD record
ord-77dbcab9c8b4481aaacbf804ba142cb9
Source dataset
uspto-grants-2010_04
Patent number
US07691893B2

Reaction notes

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