Hydrochloric Acid → HCID 75234083, compound

HRID 639860Notes

Reaction equation

HRID 639860 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]23[CH2:15][C:14]2([CH2:16][O:17][CH2:18][CH3:19])[CH2:13][NH:12][CH2:11][CH2:10]3)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl>C(Cl)Cl>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C:9]23[CH2:15][C:14]2([CH2:16][O:17][CH2:18][CH3:19])[CH2:13][NH:12][CH2:11][CH2:10]3)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 56657240HCID 56657240, compound

Product 1

HCID 75234083HCID 75234083, compoundYield 144.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (1R,6S or 1S,6R)-6-(3,4-dichlorophenyl)-1-[(ethyloxy)methyl]-3-azabicyclo[4.1.0]heptane (E19a, 11 mg) in DCM (0.2 ml) was added 1 equivalent of HCl (1M in Et2O), the solvent evaporated under vacuo and the material thus obtained triturated with Et2O to give 8.9 mg of the title compound as a white slightly hygroscopic solid.

Workup

  1. customthe solvent evaporated under vacuo
  2. customthe material thus obtained
  3. customtriturated with Et2O

Sources & evidence

ORD record
ord-0339bd0adfee4a0e8347fccf2b335df9
Source dataset
uspto-grants-2010_04
Patent number
US07691893B2

Reaction notes

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