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HRID639898

反应详情

EQUATION

反应方程式

HRID 639898 的结构方程式

REACTANTS

反应物

2
结构：C[O-].[Na+]
HCID10942334

Methanol, sodium salt

CH3NaO

结构：COc1ccc2c(Cl)nc(C#N)c(-c3ccccc3)c2c1
HCID11426414

1-Chloro-6-methoxy-4-phenylisoquinoline-3-carbonitrile

C17H11ClN2O

PRODUCTS

生成物

1
结构：COc1ccc2c(OC)nc(C#N)c(-c3ccccc3)c2c1
HCID11818604

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

To a solution of 1-chloro-6-methoxy-4-phenylisoquinoline-3-carbonitrile (50 mg) in 1 mL of DMF was added NaOMe (3 equivalents). The reaction was stirred at room temp overnight, then concentrated and purified by flash chromatography (30% EtOAc/hexanes). Trituration (ether/hexanes) of the concentrated material gave the titled compound.

WORKUP

后处理

  1. concentrationconcentrated
  2. custompurified by flash chromatography (30% EtOAc/hexanes)