Hydrochloric Acid → HCID 68422681, compound

HRID 639948Notes

Reaction equation

HRID 639948 reaction equation
C([O:3][P:4]([CH2:9][CH2:10][C:11]1[CH:16]=[C:15]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([CH2:24][CH3:25])=[CH:20][CH:19]=2)[CH:14]=[CH:13][C:12]=1[OH:26])(=[O:8])[O:5]CC)C.Cl>C(O)C>[CH2:24]([C:21]1[CH:20]=[CH:19][C:18]([CH2:17][C:15]2[CH:14]=[CH:13][C:12]([OH:26])=[C:11]([CH2:10][CH2:9][P:4](=[O:3])([OH:8])[OH:5])[CH:16]=2)=[CH:23][CH:22]=1)[CH3:25]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86620240HCID 86620240, compound

Product 1

HCID 68422681HCID 68422681, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2-[5-(4-Ethylbenzyl)-2-hydroxyphenyl]ethylphosphonic acid diethylester (0.50 g) in ethanol (5.0 mL) was added 6N—HCl (5.0 mL), and the reaction mixture was refluxed for 24 hr. Evaporation and crystallization from ethyl acetate-n-hexane gave the title compound (0.40 g) as a colorless crystal.

Workup

  1. temperaturethe reaction mixture was refluxed for 24 hr
  2. customEvaporation and crystallization from ethyl acetate-n-hexane

Sources & evidence

ORD record
ord-0823b1b1ee1b4127864779ef047d53bf
Source dataset
uspto-grants-2010_04
Patent number
US07691898B2

Reaction notes

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