Piperidine → HCID 66929778, compound

HRID 640069Notes

Reaction equation

HRID 640069 reaction equation
N1CCCCC1.C1C2C(COC(=O)[NH:23][C@@H:24]([CH:27]3[CH2:35][C:34]4[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=4)[CH2:28]3)[CH2:25][OH:26])C3C(=CC=CC=3)C=2C=CC=1>CN(C=O)C>[NH2:23][C@@H:24]([CH:27]1[CH2:35][C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:28]1)[CH2:25][OH:26]

Participants

4

Reactant 2

HCID 8082PiperidineHCID 86600473HCID 86600473, compound

Product 1

HCID 66929778HCID 66929778, compoundYield 225.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Conditions

Temperature
25 °C

Procedure

20% Piperidine in DMF (15 mL) was added to a solution of 9H-fluoren-9-ylmethyl-(1S)-1-(2,3-dihydro-1H-inden-2-yl)-2-hydroxyethylcarbamate (1.05 g, 2.63 mmol) in DMF (5 mL). The reaction was stirred at 25° C. for 19 h. After solvent evaporation, the crude product was dissolved in ethyl acetate (50 mL) and dried over MgSO4, filtered and concentrated to obtain a crude yellow oil (1.05 g). Mass Spectrum (+ESI): 179 (M+H)+.

Workup

  1. customAfter solvent evaporation
  2. dissolutionthe crude product was dissolved in ethyl acetate (50 mL)
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-cbb9555c2e6649ac93a19337aca59f24
Source dataset
uspto-grants-2010_04
Patent number
US07691884B2

Reaction notes

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