反应详情

To a solution of morpholine (1.4 g, 16.3 mmol, 1.0 eq) in DMF were added K2CO3 (5.63 g, 40.7 mmol, 2.5 eq.) and ethyl 2-bromoacetate (4.07 g, 24.4 mmol, 1.5 eq.). The mixture was stirred at RT for 16 h and quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to afford the product in 71.4% yield (2 g). LC-MS (ESI): Calculated mass: 173.2; Observed mass: 174.0 [M+H]+ (rt: 0.20 min).

1. customquenched
2. extractionextracted as in Intermediate Example 5(a)
3. distillationThe solvent was distilled off
4. customto afford the product in 71.4% yield (2 g)
5. custom174.0 [M+H]+ (rt: 0.20 min)