反应详情

To a solution of 2,6-dimethylpiperazine (500 mg, 4.378 mmol, 1.0 eq) in THF were added K2CO3 (1.2 g, 8.75 mmol, 2.2 eq.) and ethyl 2-bromoacetate (731 mg, 4.378 mmol, 1 eq). The mixture was stirred at RT for 4 h and then quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to afford the product in 34% yield (0.3 g). LC-MS (ESI): Calculated mass: 200.0; Observed mass: 201.0 [M+H]+ (rt: 0.102 min).

1. customquenched
2. extractionextracted as in Intermediate Example 5(a)
3. distillationThe solvent was distilled off
4. customto afford the product in 34% yield (0.3 g)
5. custom201.0 [M+H]+ (rt: 0.102 min)