反应详情

To a solution of morpholine (0.5 g, 5.739 mmol, 1.0 eq) in DMF were added K2CO3 (1.98 g, 14.34 mmol, 2.5 eq.) and ethyl 2-chloroacetate (1.05 g, 8.60 mmol, 1.5 eq.). The mixture was stirred at RT for 12 h. The mixture was quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to afford the product in 73.9% yield (0.735 g). LC-MS (ESI): Calculated mass: 173.21; Observed mass 174.0 [M+H]+ (rt: 0.1-0.4 min).

1. customThe mixture was quenched
2. extractionextracted as in Intermediate Example 5(a)
3. distillationThe solvent was distilled off
4. customto afford the product in 73.9% yield (0.735 g)
5. customObserved mass 174.0 [M+H]+ (rt: 0.1-0.4 min)