反应详情

温度

65 °C

A small screw cap test tube was charged with N-[3-(3-Hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-acetamide (as prepared in Example 40, 100 mg, 0.310 mmol) and THF (2 mL). To the resulting solution was added N-(4-aminophenyl)morpholine (60.83 mg, 0.341 mmol), and the mixture was stirred for 24 h at 65° C. Subsequently, the reaction mixture was cooled to room temperature and concentrated in vacuo. The crude residue was purified via flash silica gel chromatography (5% MeOH, 95% CHCl3) providing the title compound in 50% yield (75 mg, 0.155 mmol).

1. customA small screw cap test tube
2. temperatureSubsequently, the reaction mixture was cooled to room temperature
3. concentrationconcentrated in vacuo
4. customThe crude residue was purified via flash silica gel chromatography (5% MeOH, 95% CHCl3)