Water → HCID 178423479, compound

HRID 641074Notes

Reaction equation

HRID 641074 reaction equation
[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]=1[C:10]([OH:12])=O.CN(C(ON1N=[N:28][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][C:22]1=2)=[N+](C)C)C.[B-](F)(F)(F)F.[CH:35]1[CH:36]=[CH:37]C2N(O)N=[N:41][C:39]=2[CH:40]=1.[CH3:45]CN(C(C)C)C(C)C.[OH2:54]>CN(C=O)C>[N:41]1[CH:37]=[CH:36][CH:35]=[C:40]([O:54][C:25]2[CH:24]=[C:23]([NH:28][C:10]([C:2]3[NH:1][C:5]4[CH:6]=[CH:7][C:8]([CH3:45])=[CH:9][C:4]=4[N:3]=3)=[O:12])[CH:22]=[CH:27][CH:26]=2)[CH:39]=1

Participants

7

Reactant 5

HCID 962WaterHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 2332402-Benzimidazolecarboxylic acidHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

Product 1

HCID 178423479HCID 178423479, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent3×

Procedure

0.064 mmol of benzimidazolecarboxylic acid 4k was dissolved in DMF together with 0.064 mmol of the amine 5d, a solution of TBTU (0.096 mmol) in DMF, HOBT (0.026 mmol) in DMF and 0.32 mmol of DIPEA were added successively, and the mixture was stirred at room temperature. After 4 hours, 0.3 eq. of acid was added, and the mixture was stirred overnight. After further addition of 0.3 eq. of acid, the reaction mixture was diluted with water after 2 hours, and the resulting precipitate was filtered off with suction and washed with water. The resulting crude product was purified by chromatography (ethyl acetate/n-heptane: 4/6).

Workup

  1. stirringthe mixture was stirred overnight
  2. filtrationthe resulting precipitate was filtered off with suction
  3. washwashed with water
  4. customThe resulting crude product was purified by chromatography (ethyl acetate/n-heptane: 4/6)

Sources & evidence

ORD record
ord-e913fb29120e4fe1aa7a2540dd740f9e
Source dataset
uspto-grants-2010_04
Patent number
US07691870B2

Reaction notes

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