Hydrochloric Acid → HCID 67301556, compound

HRID 641232Notes

Reaction equation

HRID 641232 reaction equation
C(N[C:5](=[CH:10][C:11]1[CH:16]=[C:15]([CH3:17])[C:14]([Cl:18])=[C:13]([CH3:19])[CH:12]=1)[C:6]([O:8]C)=[O:7])(=O)C.Cl.[OH2:21]>CN1CCCC1=O>[Cl:18][C:14]1[C:15]([CH3:17])=[CH:16][C:11]([CH2:10][C:5](=[O:21])[C:6]([OH:8])=[O:7])=[CH:12][C:13]=1[CH3:19]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 67302023HCID 67302023, compound

Product 1

HCID 67301556HCID 67301556, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

29.4 g (105 mmol) methyl 2-acetylamino-3-(4-chloro-3,5-dimethylphenyl)-acrylate in 330 mL N-methyl-2-pyrrolidinone were combined with 500 mL cooled 4 M HCl, stirred for 6 h at reflux temperature and for 16 h at RT. After the reaction had ended the reaction mixture was poured onto 1650 mL water, stirred for 1 h, suction filtered and the crystals were dried at 50° C. in the vacuum drying cupboard. The product was recrystallised from toluene.

Workup

  1. temperatureat reflux temperature
  2. waitfor 16 h at RT
  3. stirringstirred for 1 h
  4. filtrationsuction filtered
  5. customthe crystals were dried at 50° C. in the vacuum
  6. customdrying cupboard
  7. customThe product was recrystallised from toluene

Sources & evidence

ORD record
ord-42df235181354a41b5b6874ca595717f
Source dataset
uspto-grants-2010_04
Patent number
US07696196B2

Reaction notes

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