HCID 66789354, compound → HCID 24763212, compound

HRID 641331Notes

Reaction equation

HRID 641331 reaction equation
C([O:5][C:6](=[O:38])[C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([C:16]2[CH:25]=[C:24]3[C:19]([O:20][CH2:21][CH2:22][N:23]3[S:26]([C:29]3[CH:34]=[C:33]([Cl:35])[CH:32]=[CH:31][C:30]=3[O:36][CH3:37])(=[O:28])=[O:27])=[N:18][CH:17]=2)=[O:15])=[CH:9][CH:8]=1)(C)(C)C>Cl>[Cl:35][C:33]1[CH:32]=[CH:31][C:30]([O:36][CH3:37])=[C:29]([S:26]([N:23]2[C:24]3[C:19](=[N:18][CH:17]=[C:16]([C:14]([NH:13][C:10]4[CH:11]=[CH:12][C:7]([C:6]([OH:38])=[O:5])=[CH:8][CH:9]=4)=[O:15])[CH:25]=3)[O:20][CH2:21][CH2:22]2)(=[O:28])=[O:27])[CH:34]=1

Participants

3

Reactant 1

HCID 66789354HCID 66789354, compound

Product 1

HCID 24763212HCID 24763212, compoundYield 86.8%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

4-{[1-(5-chloro-2-methoxy-benzenesulfonyl)-2,3-dihydro-1H-4-oxa-1,5-diaza-naphthalene-7-carbonyl]-amino}-benzoic acid tert-butyl ester (27 mg, 48 μmol) was dissolved in hydrogen chloride solution (4 M in 1,4-dioxane, 1.0 mL) and stirred at room temperature for 4 days, then the precipitate was collected by filtration and washed with ethyl acetate to produce the title compound (21 mg, 86%). White solid, MS (ISP)=502.0 (M−H)−.

Workup

  1. filtrationthe precipitate was collected by filtration
  2. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-4f05b8e36f464b0c872cbd6f6bf68d31
Source dataset
uspto-grants-2010_04
Patent number
US07696200B2

Reaction notes

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