Hydrochloric Acid → HCID 66636711, compound

HRID 641389Notes

Reaction equation

HRID 641389 reaction equation
[O:1]=[C:2]1[CH2:11][C:10]2=[CH:12][N:13]([CH2:14][C:15]([O:17]CC)=[O:16])[C:8]3[C:9]2=[C:4]([CH:5]=[CH:6][CH:7]=3)[NH:3]1.[OH-].[Li+:21].Cl>C(O)C.O>[O:1]=[C:2]1[CH2:11][C:10]2=[CH:12][N:13]([CH2:14][C:15]([O-:17])=[O:16])[C:8]3[C:9]2=[C:4]([CH:5]=[CH:6][CH:7]=3)[NH:3]1.[Li+:21]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 59257843HCID 59257843, compound

Product 1

HCID 66636711HCID 66636711, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of ethyl (4-oxo-4,5-dihydropyrrolo[4,3,2-de]quinolin-1(3H)-yl)acetate from Step G (79 mg, 0.306 mmol) in ethanol (3 mL) and water (0.5 mL) was added dropwise 1.0 N aqueous lithium hydroxide (0.34 mL, 0.34 mmol). After 5 min, 1 N aqueous HCl was added to adjust the mixture to pH 7 and the solution was concentrated in vacuo to give the title compound. MS: m/z=231 (M+1).

Workup

  1. concentrationthe solution was concentrated in vacuo

Sources & evidence

ORD record
ord-bfe9301e5ce1488da25f4c13a4486a7a
Source dataset
uspto-grants-2010_04
Patent number
US07696192B2

Reaction notes

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