HCID 117777724, compound → HCID 117777754, compound

HRID 64143Notes

Reaction equation

HRID 64143 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([N:15]2[C:19]3[CH:20]=[CH:21][C:22]([C:24]4[N:25]=[N:26][N:27]([CH:29]5[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]5)[CH:28]=4)=[CH:23][C:18]=3[N:17]=[CH:16]2)[CH:12]=[C:11]([NH:36]C(=O)C)[CH:10]=1>Cl>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([N:15]2[C:19]3[CH:20]=[CH:21][C:22]([C:24]4[N:25]=[N:26][N:27]([CH:29]5[CH2:30][CH2:31][N:32]([CH3:35])[CH2:33][CH2:34]5)[CH:28]=4)=[CH:23][C:18]=3[N:17]=[CH:16]2)[CH:12]=[C:11]([NH2:36])[CH:10]=1

Participants

3

Reactant 1

HCID 117777724HCID 117777724, compound

Product 1

HCID 117777754HCID 117777754, compoundYield 27%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of the compound of Example 164 (0.48 g, 0.91 mmol) in 6 N HCl (10 ml) was heated at 70° C. for 3 h. The mixture was quenched with NaHCO3 solution and extracted as in Example 1(d). The solvent was distilled off to afford the product in 27% yield (0.12 g).

Workup

  1. customThe mixture was quenched with NaHCO3 solution
  2. extractionextracted as in Example 1(d)
  3. distillationThe solvent was distilled off
  4. customto afford the product in 27% yield (0.12 g)

Sources & evidence

ORD record
ord-ccefbc40f59147c09cbe309fc031aee3
Source dataset
uspto-grants-2016_09
Patent number
US09447091B2

Reaction notes

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