7-Methoxyquinoline-8-carboxylic acid → 7-Hydroxyquinoline-8-carboxylic acid

HRID 64207Notes

Reaction equation

HRID 64207 reaction equation
C[O:2][C:3]1[C:12]([C:13]([OH:15])=[O:14])=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1>Br>[OH:2][C:3]1[C:12]([C:13]([OH:15])=[O:14])=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1

Participants

3

Reactant 1

HCID 687745837-Methoxyquinoline-8-carboxylic acid

Product 1

HCID 1358815557-Hydroxyquinoline-8-carboxylic acid

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

The title compound of Step A (2.9 g, 14.1 mmol) in HBr (14 mL) was heated at 90° C. for 1 h. The mixture was then concentrated washed with PhCH3 and used without further purification in subsequent steps.

Workup

  1. concentrationThe mixture was then concentrated
  2. washwashed with PhCH3
  3. customused without further purification in subsequent steps

Sources & evidence

ORD record
ord-330dccec023b4fc2842a5a3a605d164e
Source dataset
uspto-grants-2016_09
Patent number
US09447117B2

Reaction notes

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